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Ved langvarig brug er der risiko for misbrug og afhængighed og særligt ved høje doser for kognitive bivirkninger og endokrine og immunologiske bivirkninger.En rekke andre sykdommer og tilstander er assosiert med smertefull nerveskade. Hyppigst er diabetes nevropati.forslag til behandlingsalgoritme for perorale behandlinger af neuropatiske smerte
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